ITGAL antibody

Catalog No. ABIN135680

Product Details anti-ITGAL Antibody

Target: ITGAL (Integrin alpha-L (ITGAL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGAL antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Human CD11a, Mr 180 kDa

Characteristics: Mouse Anti-Human CD11a-UNLB

Purification: Purified

Immunogen: Fibronectin purified monocytes

Clone: 38

Isotype: IgG2a

Application Details

Application Notes:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IP - Reported in literature , Block - Reported in literature , Adhesion - Reported in literature , ELISA - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, PE, APC, and SPRD conjugates 10 L/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Comment:

Blocking studies, cell adhesion, cytotoxicity

Sample Volume: 1 mL

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Preservative: Without preservative

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: Store at 2-8°C

References for anti-ITGAL antibody (ABIN135680)

Jung, Zhou, Iden, Bischoff, Qu: "T cell stiffness is enhanced upon formation of immunological synapse." in: eLife, Vol. 10, (2021) (PubMed).

Target Details for ITGAL

Target: ITGAL (Integrin alpha-L (ITGAL))

Alternative Name: CD11a (ITGAL Products)

Synonyms: CD11A antibody, LFA-1 antibody, LFA1A antibody, (p180) antibody, Cd11a antibody, LFA-1A antibody, Ly-15 antibody, Ly-21 antibody, CD11a antibody, ITGAL antibody, integrin subunit alpha L antibody, integrin alpha L antibody, ITGAL antibody, Itgal antibody

Background: CD11a, also known as leukocyte function-associated antigen-1 (LFA-1), represents the 180 kDa integrin L subunit which combines with the CD18 2 integrin subunit to form the L2 integrin heterodimer. It is expressed on lymphocytes, granulocytes, monocytes, and macrophages and is upregulated on activated T cells. CD11a/LFA-1 mediates adhesion of lymphocytes to vascular endothelium and is involved in costimulation.

Pathways: Activated T Cell Proliferation, Integrin Complex