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Ezrin antibody (pTyr353)
EZR
Reactivity: Human, Mouse
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Ezrin Antibody
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Target
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Ezrin (EZR)
Binding Specificity
All epitopes for Ezrin antibodies
pTyr353
Reactivity
All reactivities for Ezrin antibodies
Human, Mouse
Host
All hosts for Ezrin antibodies
Rabbit
Clonality
All clonalities for Ezrin antibodies
Polyclonal
Conjugate
All conjugates for Ezrin antibodies
This Ezrin antibody is un-conjugated
Application
All applications for Ezrin antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous level of Ezrin only when phosphorylated at tyrosine 353.
Immunogen
Peptide sequence around phosphorylation site of pTyr353 (Q-D-Y (p) -E-E) derived from Human EZRIN. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
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Alternatives
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Application Details
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Application Notes
Western blotting: 1:500-1:1000 Immunohistochemistry: 1:50-1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
References for anti-Ezrin antibody (ABIN1355834)
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Oda, Aishima, Morimatsu, Hayashi, Shindo, Fujino, Mizuuchi, Hattori, Tanaka, Oda : "Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. " in: Human pathology , Vol. 44 , Issue 8 , pp. 1487-98 , (2013 ) (PubMed ).
Morimatsu, Aishima, Kayashima, Hayashi, Nakata, Oda, Taguchi, Tsuneyoshi, Tanaka, Oda : "Liver-intestine cadherin expression is associated with intestinal differentiation and carcinogenesis in intraductal papillary mucinous neoplasm. " in: Pathobiology : journal of immunopathology, molecular and cellular biology , Vol. 79 , Issue 2 , pp. 107-14 , (2012 ) (PubMed ).
Cui, Li, Zhang, Han : "Expression of Ezrin and phosphorylated Ezrin (pEzrin) in pancreatic ductal adenocarcinoma. " in: Cancer investigation , Vol. 28 , Issue 3 , pp. 242-7 , (2010 ) (PubMed ).
Target Details for Ezrin
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Target
Ezrin (EZR)
Alternative Name
Ezrin (EZR Products )
Synonyms
CVIL antibody, CVL antibody, VIL2 antibody, ezr antibody, vil2 antibody, wu:fc05c03 antibody, wu:fj31d06 antibody, cvil antibody, cvl antibody, Vil2 antibody, AW146364 antibody, R75297 antibody, p81 antibody, ezr.S antibody, ezrin antibody, ezrin b antibody, ezrin L homeolog antibody, EZR antibody, ezrb antibody, ezr antibody, Ezr antibody, ezr.L antibody
Background
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Molecular Weight
81 kDa
NCBI Accession
NP_001104
UniProt
P15311
Pathways
Maintenance of Protein Location
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