Integrin beta 4 antibody

Catalog No. ABIN135374

Product Details anti-Integrin beta 4 Antibody

Target: Integrin beta 4 (ITGB4)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Characteristics: The antibody detects: Integrin 4 chain (CD104), Mr 200 kDa
It is not known if the monoclonal antibody 346-11A can block the adhesion.

Endotoxin Level: Low Endotoxin

Immunogen: Tumor-associated antigen TSP-180 immunoaffinity purified from a transplantable BALB/c mouse lung cell carcinoma.1

Clone: 346-11A

Isotype: IgG2a

Application Details

Application Notes: Working Dilution:
Immunohistochemistry: 1-5 µg/mL
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Sample Volume: 1 mL

Restrictions: For Research Use only

Handling

Buffer: Product is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS.

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: -20 °C

Storage Comment: Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.

Target Details for Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Alternative Name: CD104 (ITGB4 Products)

Synonyms: AA407042 antibody, C230078O20 antibody, CD104 antibody, integrin subunit beta 4 antibody, integrin beta 4 antibody, ITGB4 antibody, Itgb4 antibody

Background: CD104 represents the integrin 4 subunit that associates non-covalently with integrin 6 (CD49f) to form the 64 integrin heterodimer. The 64 complex is expressed on the basal surface of a variety of epithelial cell types, particularly on stratified squamous epithelia. It is also found in peripheral nerves, in certain subsets of endothelial cells, and on immature thymocytes, and has been found to be associated with a number of malignant tissues. Hemidesmosomal 64 plays an important role in the adhesion of epithelial cells to basement membranes via interactions with laminin and/or kalinin anchoring filaments.

Pathways: Integrin Complex