CTLA4 antibody

Catalog No. ABIN135319

Product Details anti-CTLA4 Antibody

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: ELISA

Specificity: Mouse CD152, Mr 33-37 kDa

Characteristics: Hamster Anti-Mouse CD152-LE/AF

Endotoxin Level: Low endotoxin

Immunogen: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein

Clone: 9H10

Isotype: IgG

Application Details

Application Notes:

• Applications: ELISA - Quality tested , FC - Reported in literature , IP - Reported in literature , Costim - Reported in literature , Block - Reported in literature
• Working Dilutions: ELISA Purified (UNLB) antibody 1 g/mL

Comment:

In vitro and in vivo blocking of CTLA-4 action by soluble antibody, Promotion of in vitro CTLA-4 signaling by cross-linked antibody

Sample Volume: 1 mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of PBS

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: -20 °C

Storage Comment: Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CD152 (CTLA4 Products)

Synonyms: CTLA-4 antibody, CTLA4 antibody, CD152 antibody, Cd152 antibody, Ctla-4 antibody, Ly-56 antibody, CD antibody, CELIAC3 antibody, GRD4 antibody, GSE antibody, IDDM12 antibody, sCTLA4 antibody, cytotoxic T-lymphocyte associated protein 4 antibody, cytotoxic T-lymphocyte-associated protein 4 antibody, CTLA4 antibody, Ctla4 antibody

Background: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2.

Pathways: Cancer Immune Checkpoints