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SCIMP antibody

SCIMP Reactivity: Human FACS, IP, WB, ICC Host: Mouse Monoclonal NVL-07 unconjugated
Catalog No. ABIN1302508
  • Target See all SCIMP Antibodies
    SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
    Reactivity
    Human
    Host
    • 19
    • 3
    Mouse
    Clonality
    • 19
    • 3
    Monoclonal
    Conjugate
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SCIMP antibody is un-conjugated
    Application
    • 13
    • 13
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB), Immunocytochemistry (ICC)
    Specificity
    The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant intracellular part of human SCIMP
    Clone
    NVL-07
    Isotype
    IgG2a
  • Application Notes
    Flow cytometry: Intracellular staining.
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Draber, Vonkova, Stepanek, Hrdinka, Kucova, Skopcova, Otahal, Angelisova, Horejsi, Yeung, Weiss, Brdicka: "SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling." in: Molecular and cellular biology, Vol. 31, Issue 22, pp. 4550-62, (2011) (PubMed).

  • Target
    SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
    Alternative Name
    SCIMP (SCIMP Products)
    Synonyms
    C17orf87 antibody, UNQ5783 antibody, A430084P05Rik antibody, SLP adaptor and CSK interacting membrane protein antibody, SCIMP antibody, Scimp antibody
    Background
    SLP adaptor and CSK interacting membrane protein,SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.,NVL
    Gene ID
    388325
    UniProt
    Q6UWF3
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