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CBLC antibody (AA 444-458)

CBLC Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN129659
  • Target See all CBLC Antibodies
    CBLC (Cbl proto-oncogene C (CBLC))
    Binding Specificity
    • 7
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 444-458
    Reactivity
    • 35
    • 2
    • 1
    Human
    Host
    • 30
    • 5
    Rabbit
    Clonality
    • 30
    • 5
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    This CBLC antibody is un-conjugated
    Application
    • 34
    • 22
    • 17
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Characteristics
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 444-458 of Human Cbl-c.
    Isotype
    IgG
    Top Product
    Discover our top product CBLC Primary Antibody
  • Application Notes
    This affinity purified antibody has been tested for use in ELISA, immunohistochemistry, immunoprecipitation and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band at ~52 kDa in size corresponding to Cbl-c by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.42 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    CBLC (Cbl proto-oncogene C (CBLC))
    Abstract
    CBLC Products
    Synonyms
    CBL-3 antibody, CBL-SL antibody, RNF57 antibody, Cbl proto-oncogene C antibody, CBLC antibody, Cblc antibody
    Background
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57.  Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.  Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed).  Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.  Cbl-c knock out mice show no obvious phenotype.  Thus, the physiological role of Cbl-c is not known.
    Synonyms: Cas Br M (murine) ectropic retroviral transforming sequence c antibody, Casitas B lineage lymphoma c antibody, CBL 3 antibody, CBL SL antibody, RING finger protein 57 antibody, RNF57 antibody, SH3 binding protein CBL C antibody
    Gene ID
    23624, 125987803
    UniProt
    Q9ULV8
    Pathways
    EGFR Signaling Pathway
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