APC1 antibody (pSer355)

Catalog No. ABIN129636

Product Details anti-APC1 Antibody

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Binding Specificity: AA 351-359, pSer355

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Dog (Canine), Rat (Rattus), Sheep (Ovine)

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 351-359 of Human Apc1 protein.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and western blot.   Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 215 kDa in size corresponding to APC1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for APC1

Target: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Alternative Name: APC1 (ANAPC1 Products)

Synonyms: APC1 antibody, MCPR antibody, TSG24 antibody, DDBDRAFT_0186456 antibody, DDBDRAFT_0234263 antibody, DDB_0186456 antibody, DDB_0234263 antibody, 2610021O03Rik antibody, AI047775 antibody, AI853536 antibody, AW547281 antibody, Apc1 antibody, Mcpr antibody, tsg24 antibody, EMBRYO DEFECTIVE 2771 antibody, MOP10.10 antibody, MOP10_10 antibody, anaphase promoting complex subunit 1 antibody, E3 ubiquitin ligase antibody, ANAPC1 antibody, Anapc1 antibody, CC1G_09696 antibody, anapc1 antibody, EMB2771 antibody

Background: APC1 (also known as Anaphase promoting complex subunit 1, Cyclosome subunit 1, Protein Tsg24, Mitotic checkpoint regulator and ANAPC1) is 1 of at least 11 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.
Synonyms: Anaphase-promoting complex subunit 1 APC1 Cyclosome subunit 1 Testis-specific gene 24 protein Mitotic checkpoint regulator

Gene ID: 64682, 12056971

UniProt: Q9H1A4