ZIC2 antibody (AA 189-206)

Catalog No. ABIN129629

Product Details anti-ZIC2 Antibody

Target: ZIC2

Binding Specificity: AA 189-206

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZIC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Chimpanzee, Mouse (Murine), Rat (Rattus), Dog (Canine)

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 55 kDa in size corresponding to ZIC2 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ZIC2

Target: ZIC2

Alternative Name: ZIC-2 (ZIC2 Products)

Synonyms: HPE5 antibody, Ku antibody, cb851 antibody, fb26a03 antibody, wu:fb26a03 antibody, zic2 antibody, zic2.1 antibody, hpe5 antibody, hm:zeh0655 antibody, id:ibd5017 antibody, zic2.2 antibody, zic2l antibody, Zic family member 2 antibody, zinc finger protein of the cerebellum 2 antibody, zic family member 2 (odd-paired homolog, Drosophila), a antibody, Zic family member 2 L homeolog antibody, zic family member 2 (odd-paired homolog, Drosophila) b antibody, ZIC2 antibody, Zic2 antibody, zic2a antibody, zic2.L antibody, zic2b antibody

Background: ZIC2 (also known as zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.
Synonyms: ZIC2, zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog

Gene ID: 7546, 22547197

UniProt: O95409

Pathways: Tube Formation