PARK7/DJ1 antibody (AA 177-189)

Catalog No. ABIN129620

Product Details anti-PARK7/DJ1 Antibody

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Binding Specificity: AA 177-189

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Chimpanzee, Green Monkey (Chlorocebus sabaeus), Zebrafish (Brachydanio rerio)

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 177-189 of Human PARK7 protein.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 28 kDa in size corresponding to PARK7 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.3 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: PARK-7 (PARK7 Products)

Synonyms: DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody

Background: The product of the PARK7 gene, known as PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product, functions as a positive regulator of androgen receptor-dependent transcription.  PARK7 may also function as a redox-sensitive chaperone and as a sensor for oxidative stress and also has been reported to prevent aggregation of SNCA.   PARK7 protects neurons against oxidative stress and cell death and plays a role in fertilization. While PARK7 has no proteolytic activity, it does have a weak transforming activity.  PARK7 forms a homodimer and binds to DJBP and PIAS2.  PARK7 is part of a ternary complex containing PARK7, DJBP and AR and shows both a nuclear and cytoplasmic localization.  In some cells, PARK7 is associated with mitochondria, particularly after
Synonyms: PARK7, Parkinson disease (autosomal recessive, early onset) 7, DJ-1 mutant, and DJ-1 oncogene product

Gene ID: 11315, 31543380

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport