ING5 antibody (AA 127-140)

Catalog No. ABIN129552

Product Details anti-ING5 Antibody

Target: ING5 (Inhibitor of Growth Family, Member 5 (ING5))

Binding Specificity: AA 127-140

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This ING5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 127-140 of Human p28 ING5protein (Inhibitor of growth family, member 5). This sequence shows homology to and 2 for ING5.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 28 kDa or 26 kDa in size corresponding to variants of ING5 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.52 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-ING5 antibody (ABIN129552)

Iizuka, Sarmento, Sekiya, Scrable, Allis, Smith: "Hbo1 Links p53-dependent stress signaling to DNA replication licensing." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 140-53, (2007) (PubMed).

Target Details for ING5

Target: ING5 (Inhibitor of Growth Family, Member 5 (ING5))

Alternative Name: p28 ING5 (ING5 Products)

Background: P28 ING5 is a tumor suppressor protein similar to ING1 that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.  Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) encodes the longest isoform.
Synonyms: ING5 antibody, Inhibitor of growth family member 5 antibody

Gene ID: 84289, 18644730

UniProt: Q8WYH8

Pathways: Chromatin Binding