ING1 antibody (AA 285-296)

Catalog No. ABIN129550

Product Details anti-ING1 Antibody

Target: ING1 (Inhibitor of Growth Family, Member 1 (ING1))

Binding Specificity: AA 285-296

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This ING1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole Goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 285-296 of Human p33 ING1 protein (Inhibitor of growth family, member 1). This sequence shows 100% homology to all splice variants for ING1.

Isotype: IgG

Application Details

Application Notes: This affinity-purified antibody has been tested for use in ELISA and western blotting using over expressed cell lysates. Expect a band approximately 47 kDa, 33 kDa or 24 kDa in size corresponding to variants of ING1 by western blotting in the appropriate cell lysate or extract. Specific conditions for other applications should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ING1

Target: ING1 (Inhibitor of Growth Family, Member 1 (ING1))

Alternative Name: p33 ING1 (ING1 Products)

Synonyms: p24ING1c antibody, p33 antibody, p33ING1 antibody, p33ING1b antibody, p47 antibody, p47ING1a antibody, p33ING1c antibody, zgc:136918 antibody, ING1 antibody, 2610028J21Rik antibody, AA407184 antibody, AI875420 antibody, mING1h antibody, p33Ing1 antibody, p37Ing1b antibody, xing1 antibody, inhibitor of growth family member 1 antibody, inhibitor of growth family, member 1 antibody, inhibitor of growth family member 1 S homeolog antibody, ING1 antibody, Ing1 antibody, ing1 antibody, ing1.S antibody

Background: P33 ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53-signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.  The accession number listed below is for variant (4) that encodes the longest isoform (D).   Other synonyms for p33 ING1 include p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a, growth inhibitor ING1, inhibitor of growth 1, tumor suppressor ING1 and growth inhibitory protein ING1.
Synonyms: Growth inhibitory protein ING1 antibody, Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds antibody, ING 1 antibody, Inhibitor of growth 1 antibody, Inhibitor of growth family member 1 antibody

Gene ID: 3621, 38201661

UniProt: Q9UK53

Pathways: Protein targeting to Nucleus, Autophagy