MTBP antibody (AA 667-812)

Catalog No. ABIN129549

Product Details anti-MTBP Antibody

Target: MTBP (MDM2 Binding Protein (MTBP))

Binding Specificity: AA 667-812

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Chimpanzee

Purification: ASCITES

Immunogen: This protein A purified monoclonal antibody was produced by repeated immunizations with a recombinant amino-terminal HIS_6X-tagged polypeptide corresponding to amino acid residues 667-812 of human MTBP protein.

Clone: PHL-1

Application Details

Application Notes: This antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 110 kDa in size corresponding to MTBP by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for MTBP

Target: MTBP (MDM2 Binding Protein (MTBP))

Alternative Name: MTBP (MTBP Products)

Synonyms: MDM2BP antibody, AI429604 antibody, MDM2 binding protein antibody, Mdm2, transformed 3T3 cell double minute p53 binding protein antibody, MTBP antibody, Mtbp antibody

Background: The MDM2 onco-protein is over expressed in human cancer cells and it promotes tumorigenesis by directly blocking the function of the p53 tumor suppressor.  Studies also indicate that MDM2 regulates cell prolifer-ation via p53 independent mechanisms.   MTBP (Mdm2 [Two] Binding Protein) was identified by a yeast two-hybrid screen as an MDM2 binding protein (1).  MTBP has been reported to modulate cell cycle progression by a p53 independent mechanism and suppress MDM2-mediated p53 degradation when ectopically expressed in cells (1,2).   The human MTBP gene localizes to 8q24 (3) and MTBP RNA is expressed in a wide range of tissues, with highest being in the thymus, testes and ovaries (1).
Synonyms: MDM 2 BP antibody, MDM2 (mouse double minute 2) binding protein 104kD antibody, MDM2 (mouse double minute 2) binding protein antibody, MDM2 Binding Protein antibody, MDM2 BP antibody

Gene ID: 27085

NCBI Accession: NP_071328

UniProt: Q96DY7