KIR2DL3 antibody

Catalog No. ABIN118908

Product Details anti-KIR2DL3 Antibody

Target: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIR2DL3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity: This antibody recognises the CD158b cell surface antigen. This antibody also recognises a 50 kDa molecule, which is highly homologous to p58.2 in the extracellular domain, but has a shorter cytoplasmic tail.

Purification: Purified

Immunogen: NK cell clone E57. Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3UI myeloma cell line.

Clone: GL183

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: 1/10 - 1/50, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide and 0.1 % Bovine Serum Albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KIR2DL3

Target: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Alternative Name: CD158b / KIR2DL3 (KIR2DL3 Products)

Synonyms: CD158B2 antibody, CD158b antibody, GL183 antibody, KIR-023GB antibody, KIR-K7b antibody, KIR-K7c antibody, KIRCL23 antibody, NKAT antibody, NKAT2 antibody, NKAT2A antibody, NKAT2B antibody, p58 antibody, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 antibody, KIR2DL3 antibody

Background: CD158b is a 58kD glycoprotein expressed by a subset of NK cells (also known as p58.2 antigen). The antigen is a members of the newly described natural killer cell receptor family. CD158b functions as a receptor specific for HLA Class I molecules, including Cw3 and related HLA-C alleles. This antibody can restore the lysis by human NK clones of otherwise lysis protected targets expressing Cw3.Synonyms: KIRCL23, Killer cell immunoglobulin-like receptor 2DL3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2

Gene ID: 3804

NCBI Accession: NP_056952

UniProt: P43628

Pathways: Cancer Immune Checkpoints