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NLRP1 antibody (N-Term)
NLRP1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NLRP1 Antibody
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Target
See all NLRP1 Antibodies
NLRP1
(NLR Family, Pyrin Domain Containing 1 (NLRP1))
Binding Specificity
All epitopes for NLRP1 antibodies
AA 2-25, N-Term
Reactivity
All reactivities for NLRP1 antibodies
Human
Host
All hosts for NLRP1 antibodies
Rabbit
Clonality
All clonalities for NLRP1 antibodies
Polyclonal
Conjugate
All conjugates for NLRP1 antibodies
This NLRP1 antibody is un-conjugated
Application
All applications for NLRP1 antibodies
Western Blotting (WB)
Specificity
Recognizes human NLRP1/NALP1.
Cross-Reactivity
Human
No Cross-Reactivity
Mouse (Murine)
Cross-Reactivity (Details)
Does not cross-react with mouse NLRP1/NALP1.
Immunogen
Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) at the N-terminus of human NLRP1/NALP1.
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
In PBS containing 10 % glycerol and 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date
12 months
Target Details for NLRP1
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Target
NLRP1
(NLR Family, Pyrin Domain Containing 1 (NLRP1))
Alternative Name
NLRP1/NALP1 (NLRP1 Products )
Synonyms
CARD7 antibody, CIDED antibody, CLR17.1 antibody, DEFCAP antibody, DEFCAP-L/S antibody, NAC antibody, NALP1 antibody, PP1044 antibody, SLEV1 antibody, VAMAS1 antibody, NLR family pyrin domain containing 1 antibody, NLRP1 antibody, Nlrp1 antibody
Background
NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
UniProt
Q9C000
Pathways
Positive Regulation of Endopeptidase Activity , Inflammasome
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