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Caspase 1 (p10) antibody

CASP-1 (p10) Reactivity: Mouse WB Host: Mouse Monoclonal Casper-2 unconjugated
Catalog No. ABIN1169386
  • Target See all Caspase 1 (p10) (CASP-1 (p10)) products
    Caspase 1 (p10) (CASP-1 (p10))
    Reactivity
    • 48
    • 34
    • 32
    • 16
    Mouse
    Host
    • 48
    • 1
    Mouse
    Clonality
    • 48
    • 1
    Monoclonal
    Conjugate
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    This Caspase 1 (p10) antibody is un-conjugated
    Application
    • 49
    • 28
    • 26
    • 26
    • 9
    • 6
    • 6
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.
    Cross-Reactivity
    Mouse (Murine)
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Purity
    >95 % (SDS-PAGE)
    Immunogen
    Recombinant mouse caspase-1.
    Clone
    Casper-2
    Isotype
    IgG2a
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Chevriaux, Pilot, Derangère, Simonin, Martine, Chalmin, Ghiringhelli, Rébé: "Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction." in: Frontiers in cell and developmental biology, Vol. 8, pp. 167, (2020) (PubMed).

    Liu, Lu, Chen, Muthuraj, Li, Pattabiraman, Zempleni, Kachman, Natarajan, Yu: "Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice." in: Nutrients, Vol. 12, Issue 2, (2020) (PubMed).

    Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." in: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

    Wong, Li, Rao, Yang, Cheng, Lin, Cheng, Chen, Hua: "Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome." in: Frontiers in immunology, Vol. 9, pp. 1920, (2018) (PubMed).

    Freeman, Guo, David, Brickey, Jha, Ting: "NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes." in: The Journal of experimental medicine, Vol. 214, Issue 5, pp. 1351-1370, (2017) (PubMed).

    Yabal, Müller, Adler, Knies, Groß, Damgaard, Kanegane, Ringelhan, Kaufmann, Heikenwälder, Strasser, Groß, Ruland, Peschel, Gyrd-Hansen, Jost: "XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation." in: Cell reports, Vol. 7, Issue 6, pp. 1796-808, (2014) (PubMed).

  • Target
    Caspase 1 (p10) (CASP-1 (p10))
    Alternative Name
    Caspase-1 p10 (CASP-1 (p10) Products)
    Background
    Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
    UniProt
    P29452
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