SIRT2 antibody

Catalog No. ABIN1169092

Product Details anti-SIRT2 Antibody

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Recognizes human sirtuin 2. Detects a band of ~45 kDa by Western blot.

Cross-Reactivity: Human

Sterility: 0.2 μm filtered

Immunogen: Recombinant human sirtuin 2.

Clone: S2R233-1

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Alternative Name: Sirtuin 2 (SIRT2 Products)

Synonyms: CG5085 antibody, D.mel2 antibody, Dmel\\CG5085 antibody, SIRT2 antibody, dSIRT2 antibody, sir2 antibody, Sirt2 antibody, BmSirt2 antibody, AtSRT2 antibody, SIRTUIN 2 antibody, T2K12.8 antibody, sirtuin 2 antibody, SIR2 antibody, SIR2L antibody, SIR2L2 antibody, 5730427M03Rik antibody, Sir2l antibody, wu:fb57d05 antibody, zgc:55966 antibody, zgc:77003 antibody, Sirtuin 2 antibody, sirtuin 2 antibody, sirtuin 2 S homeolog antibody, NAD-dependent deacetylase sirtuin 2 homolog antibody, sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) antibody, Sirt2 antibody, SIRT2 antibody, sirt2.S antibody, SRT2 antibody, sirt2 antibody

Background: Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.

UniProt: Q8IXJ6