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NOTCH2 antibody

NOTCH2 Reactivity: Human, Mouse FACS Host: Rat Monoclonal 16F11 unconjugated
Catalog No. ABIN1169006
  • Target See all NOTCH2 Antibodies
    NOTCH2 (Notch 2 (NOTCH2))
    Reactivity
    • 65
    • 49
    • 30
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 75
    • 3
    • 2
    • 1
    • 1
    Rat
    Clonality
    • 74
    • 5
    • 2
    Monoclonal
    Conjugate
    • 38
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOTCH2 antibody is un-conjugated
    Application
    • 48
    • 30
    • 26
    • 26
    • 16
    • 13
    • 11
    • 11
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    Recognizes human and mouse endogenous Notch-2 receptor.
    Cross-Reactivity
    Human, Mouse (Murine)
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Purity
    >95 % (SDS-PAGE)
    Immunogen
    Recombinant mouse Notch2:Fc .
    Clone
    16F11
    Isotype
    IgG1
    Top Product
    Discover our top product NOTCH2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Ribeiro, Hasan, Wilson, Boucontet, Pereira, Lesjean-Pottier, Satoh-Takayama, Di Santo, Vosshenrich: "Cutting edge: Thymic NK cells develop independently from T cell precursors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 9, pp. 4993-7, (2010) (PubMed).

    Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: "Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7212-22, (2009) (PubMed).

  • Target
    NOTCH2 (Notch 2 (NOTCH2))
    Alternative Name
    Notch2 (NOTCH2 Products)
    Synonyms
    AGS2 antibody, HJCYS antibody, hN2 antibody, AI853703 antibody, N2 antibody, notch6 antibody, sb:cb884 antibody, neurogenic locus notch homolog protein 2 antibody, notch 2 antibody, notch 3 antibody, LOC581186 antibody, NOTCH2 antibody, notch3 antibody, Notch2 antibody, notch2 antibody
    Background
    Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
    UniProt
    O35516
    Pathways
    Notch Signaling, Stem Cell Maintenance
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