This antibody reacts with Pancreatic Polypeptide. It stains the periphery of islets, exocrine pancreatic parenchyma, and the epithelium of small and medium sized ducts and acinar cells. Cellular Localization: Cytoplasmic.
Purification
Purified
Immunogen
Synthetic Human Pancreatic Polypeptide conjugated to Keyhole Limpet Hemocyanin.
PPY
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
Biotin
Application Notes
Immunohistochemistry on Frozen and Paraffin Embedded Sections: diluted of 1/25-1/50 inan ABC method (30 minutes at room temperature)Recommended Positive Control: Pancreas. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one mounth or (in aliquots) at -20 °C for longer.
Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma levels of this hormone have been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.Synonyms: Obinepitide, PNP, PPY, Pancreatic polypeptide