ITM2B antibody
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- Target See all ITM2B Antibodies
- ITM2B (Integral Membrane Protein 2B (ITM2B))
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Reactivity
- Human
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Host
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Chicken
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Clonality
- Polyclonal
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Conjugate
- This ITM2B antibody is un-conjugated
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Application
- Immunohistochemistry (Frozen Sections) (IHC (fro))
- Sequence
- CSRTVKKNII EEN
- Specificity
- The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.
- Purification
- Affinity chromatography.
- Immunogen
- Peptide coupled to carrier protein.
- Top Product
- Discover our top product ITM2B Primary Antibody
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anti-Integral Membrane Protein 2B (ITM2B) (Internal Region) antibody
Verified ITM2B Reactivity: Human ELISA, WB, IHC, FACS, IF Host: Goat Polyclonal unconjugated
anti-Integral Membrane Protein 2B (ITM2B) (AA 81-148) antibodyITM2B Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Integral Membrane Protein 2B (ITM2B) antibodyITM2B Reactivity: Human, Mouse, Rat ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Integral Membrane Protein 2B (ITM2B) (AA 218-247), (C-Term) antibodyITM2B Reactivity: Mouse WB, IHC (p) Host: Rabbit Polyclonal RB32712 unconjugated
anti-Integral Membrane Protein 2B (ITM2B) (AA 1-266) antibodyITM2B Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Integral Membrane Protein 2B (ITM2B) (AA 1-266) antibodyITM2B Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Integral Membrane Protein 2B (ITM2B) (AA 146-245) antibodyITM2B Reactivity: Human ELISA, WB Host: Mouse Monoclonal 1A10 unconjugated
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- Application Notes
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Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg /ml
- Buffer
- PBS, pH 7.2, containing 0.09 % sodium azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.
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- Target
- ITM2B (Integral Membrane Protein 2B (ITM2B))
- Alternative Name
- ITM2B (ITM2B Products)
- Background
- The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI
- Gene ID
- 9445
- NCBI Accession
- NP_068839
- UniProt
- Q9Y287
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