Apo(a) antibody
apo(a)
Reactivity: Mammalian
WB, EIA
Host: Sheep
Polyclonal
unconjugated
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- Target See all Apo(a) (apo(a)) Antibodies
- Apo(a) (apo(a)) (Apolipoprotein A (apo(a)))
- Reactivity
- Mammalian
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Host
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Sheep
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Clonality
- Polyclonal
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Conjugate
- This Apo(a) antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- Specifically binds to human Lp(a) and apo(a). No cross-reaction to Apo B-100/48, minor to plasminogen.
- Purification
- Human Apo (a) Sepharose affinity column. Cross-reactivity to plasminogen was removed by passing plasminogen Sepharose affinity column.
- Top Product
- Discover our top product apo(a) Primary Antibody
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- Application Notes
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Suitable for use in ELISA (1: 7,500-1: 60,000), Western blot and conjugation purposes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL (OD280nm, E0.1% = 1.35)
- Buffer
- 75 mM PBS, 75 m mM Sodium chloride, pH 7.2 containing 0.02 % Sodium azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Apo(a) (apo(a)) (Apolipoprotein A (apo(a)))
- Alternative Name
- Apolipoprotein(a) / LP(a) (apo(a) Products)
- Synonyms
- AK38 antibody, APOA antibody, LP antibody, Apo(a) antibody, Lp(a) antibody, lipoprotein(a) antibody, LPA antibody
- Background
- Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis.Synonyms: Apo(a), LPA
- Gene ID
- 4018
- NCBI Accession
- NP_005568
- UniProt
- P08519
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