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PRKDC antibody (Catalytic Subunit)

Name: PRKDC antibody (Catalytic Subunit)
SKU: ABIN1112714
Price: 308 USD
Availability: InStock

PRKDC Reactivity: Mouse WB, IHC, IHC (p), ICC Host: Mouse Monoclonal N9 unconjugated

IHC (p)

Immunocytochemistry (ICC) image for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (Catalytic Subunit) antibody (ABIN1112714) (PRKDC antibody (Catalytic Subunit))

ICC

Image no. 3 for anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (Catalytic Subunit) antibody (ABIN1112714) (PRKDC antibody (Catalytic Subunit))

3 images

Catalog No. ABIN1112714

Datasheet as PDF

Target See all PRKDC Antibodies

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
Binding Specificity
26

13

12

7

6

5

4

4

4

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Catalytic Subunit
Reactivity
165

87

47

5

2

2

2

2

1
Mouse
Host
154

21

3

2
Mouse
Compatible Secondaries
Clonality
151

29
Monoclonal
Conjugate
92

11

10

7

5

4

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3
This PRKDC antibody is un-conjugated
Application
82

67

56

32

29

28

27

24

14

12

7

6

5

4

2

2

2

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Immunogen

Recombinant DNA-PKcs protein.

Clone

N9

Isotype

IgG2a

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anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (pThr2647) antibody
PRKDC Reactivity: Human ELISA, WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibody
PRKDC Reactivity: Human, Mouse ELISA, WB, IHC, IF Host: Rabbit Polyclonal unconjugated

Application Notes

WB (1:1000), IHC-P (1:200), ICC (1:100). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions

For Research Use only
Format

Liquid

Buffer

TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Preservative

Sodium azide, Thimerosal (Merthiolate)

Storage

4 °C/-20 °C

Storage Comment

Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date

12 months
Target

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Abstract

PRKDC Products

Synonyms

DNA-PKcs antibody, DNAPK antibody, DNPK1 antibody, HYRC antibody, HYRC1 antibody, XRCC7 antibody, p350 antibody, DNA-PKCS antibody, dna-pkcs antibody, dnapk antibody, dnpk1 antibody, hyrc antibody, hyrc1 antibody, prkdc-A antibody, xrcc7 antibody, PRKDC antibody, AI326420 antibody, AU019811 antibody, DNAPDcs antibody, DOXNPH antibody, dxnph antibody, p460 antibody, scid antibody, slip antibody, protein kinase, DNA-activated, catalytic polypeptide antibody, protein kinase, DNA-activated, catalytic polypeptide L homeolog antibody, DNA-dependent protein kinase catalytic subunit antibody, protein kinase, DNA activated, catalytic polypeptide antibody, PRKDC antibody, prkdc.L antibody, LOC100633457 antibody, Prkdc antibody

Background

DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Anderson and Lees-Miller (1992) noted that DNA-PK had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. It acts as a molecular sensor for DNA damage, and it may also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage.

Pathways

DNA Damage Repair, Production of Molecular Mediator of Immune Response