TSFM antibody (N-Term)

Catalog No. ABIN1109361

Product Details anti-TSFM Antibody

Target: TSFM (Ts Translation Elongation Factor, Mitochondrial (TSFM))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSFM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequence: KQAEIWLHKE AQKEGWSKAA KLQGRKTKEG LIGLLQEGNT TVLVEVNCET

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, African clawed frog, Bovine, ZebrafishSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TSFM antibody: synthetic peptide directed towards the N terminal of human TSFM.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TSFM

Target: TSFM (Ts Translation Elongation Factor, Mitochondrial (TSFM))

Alternative Name: TSFM (TSFM Products)

Synonyms: EF-Ts antibody, EF-TsMt antibody, EFTS antibody, zgc:158429 antibody, EFTSMT antibody, 2310050B20Rik antibody, 9430024O13Rik antibody, EF-TS antibody, EF-Tsmt antibody, 2A3-2 antibody, Elongation factor Ts, mitochondrial antibody, Ts translation elongation factor, mitochondrial antibody, Ts translation elongation factor, mitochondrial L homeolog antibody, pco103788 antibody, tsfm antibody, tsfm.L antibody, TSFM antibody, Tsfm antibody

Background: The TSFM gene encodes a protein that is expressed in all tissues, with the highest levels of expression in skeletal muscle, liver, and kidney. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3). Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexesSynonyms: EF-Ts, EF-TsMt, Elongation factor Ts mitochondrial

Gene ID: 10102

NCBI Accession: NP_005717