Synaptophysin antibody

Catalog No. ABIN1109181

Product Details anti-Synaptophysin Antibody

Target: Synaptophysin (SYP)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with human and mouse Synaptophysin.

Purification: Protein A agarose

Immunogen: Purified synaptic vesicle fraction from guinea pig cerebrum

Clone: 171B5

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservtives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: Synaptophysin / SYP (SYP Products)

Synonyms: syp-B antibody, xsypii antibody, MGC86267 antibody, MRXSYP antibody, A230093K24Rik antibody, AI848995 antibody, Syn antibody, p38 antibody, Syp1 antibody, mrxsyp antibody, syp antibody, xsypi antibody, synaptophysin S homeolog antibody, synaptophysin antibody, synaptophysin L homeolog antibody, synaptophysin a antibody, syp.S antibody, SYP antibody, syp antibody, Syp antibody, syp.L antibody, sypa antibody

Background: Synaptophysin (also referred to as SVP38 and p38) is an acidic Ca2+ binding glycoprotein of about 38 kDa which exist largely in synaptic vesicles. It has 4 transmembrane regions and is reported to be a major cholesterol-binding protein in synaptic vesicles. Synaptophysin may regulate synaptic exocytosis by competing with proteins such as SNAP25 and syntaxins to bind to synaptobrevin (vesicle-associated membrane protein, or VAMP). It may also participate in synaptic endocytosis, which contributes to rapid recycling of synaptic vesicle.Synonyms: Major synaptic vesicle protein p38, Neuroendocrine Marker

Gene ID: 6855

NCBI Accession: NP_003170

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity