Siglec H antibody (FITC)
Reactivity: Mouse
IHC (fro)
Host: Rat
Monoclonal
440c
FITC
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- Target See all Siglec H products
- Siglec H
- Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This Siglec H antibody is conjugated to FITC
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Application
- Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity (Details)
- Species reactivity (tested):Mouse
- Purification
- Protein G
- Clone
- 440c
- Isotype
- IgG2b
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anti-Siglec H (AA 109-309) antibody
Reactivity: Mouse WB Host: Rat Monoclonal ABM2B55 unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % sodium azide, 1 % bovine serum albumin
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2 - 8 °C.
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- Target
- Siglec H
- Alternative Name
- Siglec-H (Siglec H Products)
- Synonyms
- 6430529G09Rik antibody, Siglec-H antibody, sialic acid binding Ig-like lectin H antibody, Siglech antibody
- Background
- Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo.
- UniProt
- Q3Y597
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