MAMLD1 antibody (N-Term)

Catalog No. ABIN1108113

Product Details anti-MAMLD1 Antibody

Target: MAMLD1 (Mastermind-Like Domain Containing 1 (MAMLD1))

Binding Specificity: N-Term

Reactivity: Human, Dog, Mouse, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAMLD1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LEELTKIQDP SPNELDLEKI LGTKPEEPLV LDHPQATLST TPKPSVQMSH

Cross-Reactivity (Details): Species reactivity (expected):Mouse, African clawed frog, DogSpecies reactivity (tested):Human

Purification: Purified using Protein A affinity column

Immunogen: The immunogen for anti-CXORF6 antibody: synthetic peptide directed towards the N terminal of human CXORF6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for MAMLD1

Target: MAMLD1 (Mastermind-Like Domain Containing 1 (MAMLD1))

Alternative Name: MAMLD1 (MAMLD1 Products)

Synonyms: CG1 antibody, CXorf6 antibody, F18 antibody, HYSP2 antibody, G630014P10Rik antibody, mastermind like domain containing 1 antibody, mastermind-like domain containing 1 antibody, MAMLD1 antibody, Mamld1 antibody

Background: Mastermind-like domain-containing protein 1 or CXorf6 transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. MAMLD1 is expressed in fetal brain, fetal ovary, fetal testis, adult brain, ovary, skin, testis, uterus and highly expressed in skeletal muscle. Defects in MAMLD1 are a cause of X-linked hypospadias type 2 (HYSP2). Hypospadias is a common malformation in which the urethra opens on the ventral side of the penis. It is considered a complex disorder with both genetic and environmental factors involved in the pathogenesis. Hypospadias can occur alone on an apparently multifactorial basis or as part of syndromes.Mastermind-like domain-containing protein 1Synonyms: CXorf6, F18, Mastermind-like domain-containing protein 1, Protein CG1

Gene ID: 10046

NCBI Accession: NP_005482