IL27 antibody

Catalog No. ABIN1107834

Product Details anti-IL27 Antibody

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL27 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Recognizes both natural and recombinant Human IL-27

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ion Exchange Chromatography.

Sterility: 0.22 μm filtered

Immunogen: Recombinant Human IL-27.

Clone: B-G49

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IL27

Target: IL27 (Interleukin-27 Subunit alpha (IL27))

Alternative Name: Interleukin-27 / IL27A (IL27 Products)

Synonyms: IL-27 antibody, IL-27A antibody, IL27A antibody, IL27p28 antibody, IL30 antibody, p28 antibody, EUROIMAGE1875335 antibody, IL25 antibody, IL27 antibody, IL27w antibody, R33729_1 antibody, SF20 antibody, IL-27p28 antibody, Il30 antibody, interleukin 27 antibody, myeloid derived growth factor antibody, IL27 antibody, MYDGF antibody, Il27 antibody

Background: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28

Gene ID: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9