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HLA-DMA antibody

HLA-DMA Reactivity: Mouse WB, IHC (p), IP, FACS, Func, IHC (fro) Host: Rat Monoclonal M5-114 unconjugated
Catalog No. ABIN1107564
  • Target See all HLA-DMA Antibodies
    HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
    Reactivity
    • 17
    • 3
    • 3
    • 2
    • 1
    Mouse
    Host
    • 15
    • 2
    • 1
    Rat
    Clonality
    • 16
    • 2
    Monoclonal
    Conjugate
    • 13
    • 3
    • 1
    • 1
    This HLA-DMA antibody is un-conjugated
    Application
    • 12
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    The antibody reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein-G affinity chromatography
    Purity
    > 95 % pure by SDS-PAGE
    Immunogen
    Activated C57BL/6 mouse spleen cells
    Clone
    M5-114
    Isotype
    IgG2b
    Top Product
    Discover our top product HLA-DMA Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized
    Preservative
    Azide free
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
    Abstract
    HLA-DMA Products
    Synonyms
    RT1.Ma antibody, RT1.DMa antibody, HLA-DMA antibody, H-2Ma antibody, H2-Ma antibody, D6S222E antibody, DMA antibody, HLADM antibody, RING6 antibody, RT1 class II, locus DMa antibody, SLA-DM alpha chain antibody, major histocompatibility complex, class II, DM alpha antibody, histocompatibility 2, class II, locus DMa antibody, RT1-DMa antibody, SLA-DMA antibody, DLA-DMA antibody, H2-DMa antibody, HLA-DMA antibody
    Background
    MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.Synonyms: DM alpha chain, DMA, HLA class II histocompatibility antigen, MHC class II antigen DMA, RING6, Really interesting new gene 6 protein
    Gene ID
    3108
    NCBI Accession
    NP_006111
    UniProt
    P28067
    Pathways
    Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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