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HLA B7 antibody

HLA B7 Reactivity: Human IHC (p) Host: Mouse Monoclonal EP-4 unconjugated
Catalog No. ABIN1107562
  • Target See all HLA B7 Antibodies
    HLA B7 (HLA Class I B7 Alpha (HLA B7))
    Reactivity
    • 13
    • 3
    • 2
    • 2
    • 2
    Human
    Host
    • 11
    • 2
    Mouse
    Clonality
    • 11
    • 2
    Monoclonal
    Conjugate
    • 7
    • 4
    • 2
    This HLA B7 antibody is un-conjugated
    Application
    • 10
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody clone EP-4 recognizes the HLA-B27 cell surface antigen on Human cells. Since EP-4 recognizes the HLA-B27 antigen, it may be used to HLA type human lymphoctyes. Approximately 60 % of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in Human lymphocytes. Monoclonal antibody EP-4 recognizes the HLA-B27 antigen expressed on individuals with this HLA haplotype.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Purified
    Immunogen
    Native purified from lymphocytes of HLA-B27 individual.
    Clone
    EP-4
    Isotype
    IgM
    Top Product
    Discover our top product HLA B7 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or -20 °C for longer.
  • Target
    HLA B7 (HLA Class I B7 Alpha (HLA B7))
    Abstract
    HLA B7 Products
    Synonyms
    AS antibody, HLAB antibody, SPDA1 antibody, major histocompatibility complex, class I, B antibody, HLA-B antibody
    Background
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been describedSynonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7
    Gene ID
    3106
    NCBI Accession
    NP_005505
    UniProt
    P01889
    Pathways
    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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