CMV gB antibody

Catalog No. ABIN110746

Product Details

Target: CMV gB

Reactivity: Cytomegalovirus (CMV)

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Neutralization (Neut)

Specificity: The antibody is specific for Cytomegalovirus glycoprotein B late neutralizing antigen. Reacts with MRC-5 infected cells but not uninfected cells. This antibody has been found to be Neutralizing.

Purification: Affinity Chromatography on Protein A

Immunogen: Human CMV extracts.

Clone: HCMV37

Isotype: IgG2a

Application Details

Application Notes: Immunofluorescence. Reactive only in acetone fixed CMV infected cells or frozen sections. ELISA. Immunohistochemistry on frozen sections. Neutralization.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: This product is photosensitive and should be protected from light

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C DO NOT FREEZE!

Target Details

Target: CMV gB

Target Type: Viral Protein

Background: Human Cytomegalovirus (HCMV) glycoprotein B (gB) is an abundant virion envelope protein that has been shown to be essential for the infectivity of HCMV. HCMV gB is also one of the most immunogenic virus-encoded proteins, and a significant fraction of virus neutralizing antibodies are directed at gB. Glycoprotein B (gB) is the main antigenic protein within the envelope of HCMV. It is required for CMV mediated membrane fusion along with the gH/gL complex. The unprocessed precursor of HCMV gB is 906 amino acids in length, wit a MW of approximately 100 kDa.Synonyms: Cytomegalovirus, Glycoprotein B, HCMV, HHV5, UL55

Gene ID: 1487750

NCBI Accession: NP_039989

UniProt: P06473