Cyclin D1 antibody
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- Target See all Cyclin D1 (CCND1) Antibodies
- Cyclin D1 (CCND1)
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Cyclin D1 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody reacts with human Cyclin D1 (36 kDa). This clone 5D4 recognizes human Cyclin D1, D2 and mouse Cyclin D1, D2, but not human and mouse Cyclin D3.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse
- Purification
- Protein A agarose
- Immunogen
- Recombinant human PRAD1/Cyclin D1
- Clone
- 5D4
- Isotype
- IgG2a
- Top Product
- Discover our top product CCND1 Primary Antibody
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anti-Cyclin D1 (CCND1) (AA 61-110) antibody
CCND1 Reactivity: Human, Mouse, Rat, Cow, Rabbit, Sheep WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (AA 68-97) antibodyCCND1 Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal RB8066 unconjugated
anti-Cyclin D1 (CCND1) (AA 1-295) antibodyCCND1 Reactivity: Human WB, ELISA, IHC, FACS Host: Mouse Monoclonal 1F7F5 unconjugated
anti-Cyclin D1 (CCND1) (AA 167-295) antibodyCCND1 Reactivity: Human ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 3B6G3 unconjugated
anti-Cyclin D1 (CCND1) (AA 96-295) antibodyCCND1 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Cyclin D1 (CCND1) antibodyKO Validated CCND1 Reactivity: Human WB, IHC, IF, IP Host: Rabbit Monoclonal unconjugated
anti-Cyclin D1 (CCND1) (C-Term) antibodyCCND1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Cyclin D1 (CCND1) (AA 68-97) antibodyCCND1 Reactivity: Human, Mouse WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Cyclin D1 (CCND1) antibodyCCND1 Reactivity: Human, Mouse, Rat, Monkey WB, IHC, FACS, IF, StM Host: Mouse Monoclonal DCS-6 unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2
- Preservative
- Azide free
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store (in aliquots) at -20 °C.
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- Target
- Cyclin D1 (CCND1)
- Alternative Name
- Cyclin D1 (CCND1 Products)
- Background
- Cyclin D1, also known as Bcl-1, CCND1, or PRAD-1, is a 36 kDa nuclear protein that plays a key regulatory role during the G1 phase of the cell cycle by regulating the activity of Cdk proteins. Cyclin D1 forms a complex with Cdk4, then binds to and phosphorylates Rb protein, triggering cells to progress from G0/G1 to S and thus driving cellular proliferation. Cyclin D1 protein overexpression is found in the majority of human breast cancers and is usually linked with poor prognosis. Overexpression of cyclin D1 is a well-established criterion for the diagnosis of Mantle Cell Lymphoma, and also has been used to distinguish malignant breast carcinomas from premalignant breast lesions.Synonyms: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1
- Gene ID
- 595
- NCBI Accession
- NP_444284
- UniProt
- P24385
- Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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