CLP antibody, 1810074P22Rik antibody, 2010004C08Rik antibody, Clp antibody, coactosin like F-actin binding protein 1 antibody, coactosin-like 1 (Dictyostelium) antibody, coactosin-like F-actin binding protein 1 antibody, COTL1 antibody, Cotl1 antibody
Background
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.Synonyms: CLP, COTL1