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CXCR2 antibody (Middle Region)
CXCR2
Reactivity: Human
WB, IP, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CXCR2 Antibody
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Target
See all CXCR2 Antibodies
CXCR2
(Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
Binding Specificity
All epitopes for CXCR2 antibodies
Middle Region
Reactivity
All reactivities for CXCR2 antibodies
Human
Host
All hosts for CXCR2 antibodies
Rabbit
Clonality
All clonalities for CXCR2 antibodies
Polyclonal
Conjugate
All conjugates for CXCR2 antibodies
This CXCR2 antibody is un-conjugated
Application
All applications for CXCR2 antibodies
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects CD182 / IL8RB (middle). No cross reactivity with other proteins.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Immunogen affinity purified
Immunogen
Synthetic peptide mapping at the middle region of human CXCR2 .Remarks: Sequence is identical to the related rat and mouse sequence.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer
5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
Preservative
Sodium azide, Thimerosal (Merthiolate)
Precaution of Use
This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target Details for CXCR2
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Target
CXCR2
(Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
Alternative Name
CD182 / IL8RB (CXCR2 Products )
Synonyms
CD182 antibody, CDw128b antibody, CMKAR2 antibody, IL8R2 antibody, IL8RA antibody, IL8RB antibody, CXC-R2 antibody, CXCR-2 antibody, CD128 antibody, CDw128 antibody, Cmkar2 antibody, Gpcr16 antibody, IL-8Rh antibody, IL-8rb antibody, Il8rb antibody, mIL-8RH antibody, C-X-C motif chemokine receptor 2 antibody, chemokine (C-X-C motif) receptor 2 antibody, Cxcr2 antibody, CXCR2 antibody
Background
CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.Synonyms: CDw128b, CXCR-2, CXCR2, GRO/MGSA receptor, IL-8 receptor type 2, IL8 receptor beta
Gene ID
3579
NCBI Accession
NP_001548
UniProt
P25025
Pathways
cAMP Metabolic Process
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