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CD14 antibody (FITC)

CD14 Reactivity: Mouse IF, Func Host: Mouse Monoclonal 14-02-14 FITC
Catalog No. ABIN1105874
  • Target See all CD14 Antibodies
    CD14
    Reactivity
    • 231
    • 38
    • 36
    • 25
    • 24
    • 23
    • 23
    • 23
    • 18
    • 16
    • 15
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    • 14
    • 14
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    • 10
    • 8
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    • 5
    • 5
    • 2
    • 1
    • 1
    Mouse
    Host
    • 203
    • 53
    • 16
    • 3
    • 1
    Mouse
    Clonality
    • 221
    • 54
    • 1
    Monoclonal
    Conjugate
    • 118
    • 31
    • 23
    • 19
    • 13
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD14 antibody is conjugated to FITC
    Application
    • 209
    • 84
    • 62
    • 50
    • 48
    • 46
    • 20
    • 15
    • 13
    • 11
    • 7
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    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Functional Studies (Func)
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein G
    Immunogen
    CD14 transfectant
    Clone
    14-02-14
    Isotype
    IgG2a
    Top Product
    Discover our top product CD14 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 1 % bovine serum albumin
    Storage
    4 °C
    Storage Comment
    Store at 2 - 8 °C.
  • Target
    CD14
    Alternative Name
    CD14 (CD14 Products)
    Background
    The CD14 receptor is a pattern recognition molecule in the innate immune response against microorganisms and other exogenous and endogenous stress factors. CD14 was characterized as a receptor for LPS. The CD14 gene consists of two exons which code for a single mRNA that is translated into a protein of 375 amino acids. The CD14 protein is composed of eleven leucin-rich repeats, which are also found in TLR and which are important in PAMP binding. In contrast to TLR, however, CD14 lacks a transmembrane domain, and thus cannot initiate intracellular signal transduction by itself. The most important CD14 signaling co-receptor is toll-like receptor 4 (TLR4), which activates, among others, the nuclear factor κB (NF-κB) inflammatory pathway. The CD14 protein is processed in the endoplasmatic reticulum and expressed as a 55 kDa glycoprotein on the cell surface via a glycosylphosphatidyl (GPI) anchor. Like other GPI-anchored proteins, CD14 accumulates on the cell surface in microdomains known as lipid rafts. CD14 is expressed pre dominantly on the surface of 'myeloid' cells, such as monocytes, macrophages and neutrophils, but at lower levels also on epithelial cells, endothelial cells and fibroblasts. CD14 is also expressed in a soluble form (sCD14). sCD14 may result from secretion of the protein before coupling to the GPI anchor or from shedding or cleavage from the surface of monocytes. sCD14 is present in the circulation and other body fluids and levels of sCD14 in plasma increase during inflammation and infection. CD14 is a molecule with a broad range of functions. In addition to functioning as a pattern recognition receptor for a variety of microbial ligands, CD14 also acts as a receptor for endogenous molecules like intercellular adhesion molecule (ICAM)-3 on the surface of apoptotic cells, amyloid peptid, ceramide, and urate crystals. Ligation of CD14 by these ligands, except for apoptotic cells, mediates activation of inflammatory responses.Synonyms: Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein
    UniProt
    P10810
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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