×
For best experience we recommend to activate Javascript in your browser.
Caspase 2 antibody (C-Term)
CASP2
Reactivity: Human, Mouse, Rat
WB, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Caspase 2 Antibody
(hide)
Target
See all Caspase 2 (CASP2) Antibodies
Caspase 2 (CASP2)
(Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
Binding Specificity
All epitopes for Caspase 2 antibodies
C-Term
Reactivity
All reactivities for Caspase 2 antibodies
Human, Mouse, Rat
Host
All hosts for Caspase 2 antibodies
Rabbit
Clonality
All clonalities for Caspase 2 antibodies
Polyclonal
Conjugate
All conjugates for Caspase 2 antibodies
This Caspase 2 antibody is un-conjugated
Application
All applications for Caspase 2 antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse. Species reactivity (tested):Human, Rat.
Purification
Immunoaffinity Chromatography
Immunogen
Synthetic peptide mapping at the C-terminal of Human Caspase 2 .Remarks: Sequence is identical to the related Rat and Mouse sequence.
Isotype
IgG
Top Product
Discover our top product CASP2 Primary Antibody
Alternatives
(show)
Application Details
(hide)
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
(hide)
Reconstitution
0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer
0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA
Preservative
Thimerosal (Merthiolate)
Precaution of Use
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Caspase 2
(hide)
Target
Caspase 2 (CASP2)
(Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
Alternative Name
Caspase-2 (CASP2 Products )
Synonyms
xCaspase-2 antibody, Caspase-2 antibody, ICH-1 antibody, Nedd2 antibody, CASP-2 antibody, ICH1 antibody, NEDD-2 antibody, NEDD2 antibody, PPP1R57 antibody, ICH-1L/1S antibody, ICH1L1S antibody, caspase 2 antibody, caspase 2 L homeolog antibody, caspase-2 antibody, CASP2 antibody, casp2.L antibody, CpipJ_CPIJ008254 antibody, Casp2 antibody
Background
Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2
Gene ID
835
NCBI Accession
NP_116764
UniProt
P42575
Pathways
Apoptosis , Caspase Cascade in Apoptosis , Neurotrophin Signaling Pathway
Recently viewed
(hide)