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Carboxy Methyl Lysine antibody

CML EIA, WB, IHC (p), IHC (fro), IF Host: Mouse Monoclonal CML26 unconjugated
Catalog No. ABIN1105660
  • Target See all Carboxy Methyl Lysine (CML) Antibodies
    Carboxy Methyl Lysine (CML)
    Host
    • 1
    • 1
    Mouse
    Clonality
    • 1
    • 1
    Monoclonal
    Conjugate
    • 2
    This Carboxy Methyl Lysine antibody is un-conjugated
    Application
    Enzyme Immunoassay (EIA), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Multispecies cross reactant.
    Purification
    Protein G Chromatography
    Immunogen
    Carboxy Methyl Lysine (CML)-KLH
    Clone
    CML26
    Isotype
    IgG1
    Top Product
    Discover our top product CML Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide, 0.1 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 2-8 °C.
  • Target
    Carboxy Methyl Lysine (CML)
    Alternative Name
    Carboxy Methyl Lysine (CML Products)
    Synonyms
    ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, PHL antibody, BCR, RhoGEF and GTPase activating protein antibody, BCR antibody
    Target Type
    Amino Acid
    Background
    CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications.Synonyms: CML, Carboxymethyl-lysine
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