Carboxy Methyl Lysine antibody
CML
EIA, WB, IHC (fro), IF, IHC (p)
Host: Mouse
Monoclonal
CML26
unconjugated
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- Target See all Carboxy Methyl Lysine (CML) Antibodies
- Carboxy Methyl Lysine (CML)
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Carboxy Methyl Lysine antibody is un-conjugated
- Application
- Enzyme Immunoassay (EIA), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Multispecies cross reactant.
- Purification
- Protein G Chromatography
- Immunogen
- Carboxy Methyl Lysine (CML)-KLH
- Clone
- CML26
- Isotype
- IgG1
- Top Product
- Discover our top product CML Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % Sodium Azide, 0.1 % BSA
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 2-8 °C.
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- Target
- Carboxy Methyl Lysine (CML)
- Alternative Name
- Carboxy Methyl Lysine (CML Products)
- Synonyms
- ALL antibody, BCR1 antibody, CML antibody, D22S11 antibody, D22S662 antibody, PHL antibody, BCR, RhoGEF and GTPase activating protein antibody, BCR antibody
- Target Type
- Amino Acid
- Background
- CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications.Synonyms: CML, Carboxymethyl-lysine
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