Hexosaminidase A antibody

Catalog No. ABIN1105521

Product Details anti-Hexosaminidase A Antibody

Target: Hexosaminidase A (HEXA)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Hexosaminidase A antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: Recognizes Beta-hexosaminidase alpha / HEXA

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Clone: 3F10

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, 0.05 % Sodium Azide, 0.5 % protein stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Hexosaminidase A

Target: Hexosaminidase A (HEXA)

Alternative Name: beta-Hexosaminidase alpha / HEXA (HEXA Products)

Synonyms: TSD antibody, fc04h11 antibody, wu:fc04h11 antibody, wu:fv09f06 antibody, si:dkey-35i22.2 antibody, HEXA antibody, Hex-1 antibody, zgc:112084 antibody, hexosaminidase subunit alpha antibody, hexosaminidase B (beta polypeptide) antibody, CUGBP Elav-like family member 6 antibody, hexosaminidase A antibody, hexosaminidase A (alpha polypeptide) antibody, beta-hexosaminidase subunit alpha-like antibody, HEXA antibody, hexb antibody, CELF6 antibody, Hexa antibody, hexa antibody, LOC100228061 antibody

Background: This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).Synonyms: Beta-N-acetylhexosaminidase subunit alpha, N-acetyl-beta-glucosaminidase subunit alpha

Molecular Weight: 60.7 kDa

Gene ID: 3073

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process