beta Amyloid antibody (N-Term)

Catalog No. ABIN1105360

Product Details anti-beta Amyloid Antibody

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Binding Specificity: AA 1-16, N-Term

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity (Details): Species reactivity (tested):Human, weakly with mouse brain

Purification: Protein-A Sepharose

Immunogen: Synthetic amyloid beta peptide corresponding to amino acids 1-16 of human amyloid beta

Clone: 2C8

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2, without preservatives

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta (Abeta Products)

Synonyms: AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN-II antibody, PN2 antibody, aaa antibody, abeta antibody, abpp antibody, ad1 antibody, appi antibody, ctfgamma antibody, cvap antibody, pn2 antibody, Abeta antibody, Abpp antibody, Adap antibody, Ag antibody, Cvap antibody, E030013M08Rik antibody, betaApp antibody, amyloid beta precursor protein antibody, amyloid beta (A4) precursor protein antibody, APP antibody, app antibody, App antibody

Background: Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ß-secretase and gamma-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.Synonyms: Amyloid beta peptide

Pathways: Inflammasome