AMD1 antibody (C-Term)

Catalog No. ABIN1105345

Product Details anti-AMD1 Antibody

Target: AMD1 (Adenosylmethionine Decarboxylase 1 (AMD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody detects AMD1 (C-term). No cross reactivity with other proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence at the C-terminal of human SAMDC .Remarks: Sequence is identical to the related mouse and rat sequence.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for AMD1

Target: AMD1 (Adenosylmethionine Decarboxylase 1 (AMD1))

Alternative Name: AMD1 (AMD1 Products)

Synonyms: ADOMETDC antibody, AMD antibody, SAMDC antibody, Amd1a antibody, Amd1b antibody, AMD1 antibody, AdoMetDC antibody, amd antibody, samdc antibody, fb26e03 antibody, si:ch211-257g8.2 antibody, wu:fb26e03 antibody, zgc:55614 antibody, 1 antibody, Amd-1 antibody, SAMDC 1 antibody, adoMetDC1 antibody, CG5029 antibody, Dmel\\CG5029 antibody, l(2)31Dc antibody, l(2)31Dd antibody, l(2)31De antibody, F16B3.10 antibody, F16B3_10 antibody, S-ADENOSYLMETHIONINE DECARBOXYLASE antibody, S-adenosylmethionine decarboxylase antibody, adenosylmethionine decarboxylase 1 antibody, S-adenosylmethionine decarboxylase 1 antibody, S-adenosyl methionine decarboxylase 2 antibody, adenosylmethionine decarboxylase 1 L homeolog antibody, S-adenosylmethionine decarboxylase antibody, AMD1 antibody, Amd1 antibody, amd1 antibody, sam2 antibody, amd1.L antibody, SamDC antibody, SAMDC antibody

Background: S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC), is a key enzyme in polyamine biosynthesis. It is localized to chromosome region 6q21-q22. SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin. It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool. SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target. Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.Synonyms: AdoMetDC, S-adenosylmethionine decarboxylase proenzyme, SAMDC

Gene ID: 262

NCBI Accession: NP_001625

UniProt: P17707

Pathways: Ribonucleoside Biosynthetic Process