ACIN1 antibody (N-Term)

Catalog No. ABIN1105223

Product Details anti-ACIN1 Antibody

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Binding Specificity: AA 1-523, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACIN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: This antibody reacts withAcinusL.

Cross-Reactivity (Details): Species reactivity (tested):Human.
Does not react with mouse (WR19L, NIH3T3) or hamster (CHO).

Purification: Protein A agarose beads

Immunogen: GST-human AcinusL fusion protein corresponding to N-terminal amino acids (1~523 a.a.)

Clone: 3H8

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for ACIN1

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Alternative Name: Acinus / ACIN1 (ACIN1 Products)

Background: Chromatin condensation and nuclear fragmentation (CCNF) are hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase-activated DNase (CAD/DFF40) and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus). The 220 kDa Acinus protein is cleaved by caspase-3 and an additional unknown protease to generate a 17 kDa peptide that which causes chromatin condensation in vitro when added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS, and AcinusS'. Acinus is ubiquitously expressed.Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670

Molecular Weight: 220 kDa

Gene ID: 22985

NCBI Accession: NP_001158286

UniProt: Q9UKV3