Prosaposin antibody (AA 325-524)
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- Target See all Prosaposin (PSAP) Antibodies
- Prosaposin (PSAP)
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Binding Specificity
- AA 325-524
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Prosaposin antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Purpose
- PSAP Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. Coli.
- Clone
- 4D5F4
- Isotype
- IgG1
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50 - 1/500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." in: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).
: "
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The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
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- Target
- Prosaposin (PSAP)
- Alternative Name
- PSAP (PSAP Products)
- Synonyms
- GLBA antibody, SAP1 antibody, AI037048 antibody, SGP-1 antibody, SGP1A antibody, cb759 antibody, wu:fa14a06 antibody, wu:fb36e02 antibody, wu:fb58g07 antibody, PSAP antibody, PSP-A antibody, SFTPA1B antibody, SP-A antibody, prosaposin antibody, surfactant protein A1 antibody, PSAP antibody, Psap antibody, psap antibody, LOC100011417 antibody, LOC100304726 antibody, LOC100526719 antibody, SFTPA1 antibody
- Background
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Description: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Aliases: GLBA, SAP1
- Molecular Weight
- 58.1kDa
- Gene ID
- 5660
- HGNC
- 5660
- UniProt
- P07602
- Pathways
- Positive Regulation of Endopeptidase Activity
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