Osteopontin antibody (AA 167-314)

Catalog No. ABIN1098149

Product Details anti-Osteopontin Antibody

Target: Osteopontin (SPP1) (Secreted phosphoprotein 1 (SPP1))

Binding Specificity: AA 167-314

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Osteopontin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: SPP1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SPP1 (AA: 167-314) expressed in E. Coli.

Clone: 7C5H12

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Osteopontin antibody (ABIN1098149)

Liersch, Gerss, Schliemann, Bayer, Schwöppe, Biermann, Appelmann, Kessler, Löwenberg, Büchner, Hiddemann, Müller-Tidow, Berdel, Mesters: "Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients." in: Blood, Vol. 119, Issue 22, pp. 5215-20, (2012) (PubMed).

Wang, Wang, Tang: "Osteopontin expression in nasopharyngeal carcinoma: its relevance to the clinical stage of the disease." in: Journal of cancer research and therapeutics, Vol. 7, Issue 2, pp. 138-42, (2011) (PubMed).

Target Details for Osteopontin

Target: Osteopontin (SPP1) (Secreted phosphoprotein 1 (SPP1))

Alternative Name: SPP1 (SPP1 Products)

Synonyms: BNSP antibody, BSPI antibody, ETA-1 antibody, OPN antibody, 2AR antibody, Apl-1 antibody, Bsp antibody, Eta antibody, OP antibody, Opn antibody, Opnl antibody, Ric antibody, Spp-1 antibody, OSP antibody, zgc:111821 antibody, secreted phosphoprotein 1 antibody, SPP1 antibody, Spp1 antibody, spp1 antibody

Background:

Description: The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.

Aliases: OPN, BNSP, BSPI, ETA-1

Molecular Weight: 35.4kDa

Gene ID: 6696

HGNC: 6696

UniProt: P10451

Pathways: Regulation of Cell Size