Mesp2 antibody (AA 37-94)

Catalog No. ABIN1098148

Product Details anti-Mesp2 Antibody

Target: Mesp2 (Mesoderm Posterior 2 Homolog (Mesp2))

Binding Specificity: AA 37-94

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mesp2 antibody is un-conjugated

Application: ELISA

Purpose: MESP2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MESP2 (AA: 37-94 ) expressed in E. Coli.

Clone: 1B3F9

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Mesp2 antibody (ABIN1098148)

Qiu, Zhou, Jiang, Ji, Ding, Lv, Liu, Tang, Cheng, Qiu: "Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis." in: Studies in health technology and informatics, Vol. 176, pp. 52-5, (2012) (PubMed).

Cornier, Staehling-Hampton, Delventhal, Saga, Caubet, Sasaki, Ellard, Young, Ramirez, Carlo, Torres, Emans, Turnpenny, Pourquié: "Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome." in: American journal of human genetics, Vol. 82, Issue 6, pp. 1334-41, (2008) (PubMed).

Target Details for Mesp2

Target: Mesp2 (Mesoderm Posterior 2 Homolog (Mesp2))

Alternative Name: MESP2 (Mesp2 Products)

Synonyms: bHLHc6 antibody, SCDO2 antibody, mesoderm posterior 2 antibody, mesoderm posterior bHLH transcription factor 2 antibody, Mesp2 antibody, MESP2 antibody

Background:

Description: This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).

Aliases: SCDO2, bHLHc6

Molecular Weight: 41.8kDa

Gene ID: 145873

HGNC: 145873

UniProt: Q0VG99