DKK3 antibody (AA 91-350)

Catalog No. ABIN1098142

Product Details anti-DKK3 Antibody

Target: DKK3

Binding Specificity: AA 91-350

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DKK3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: DKK3 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. Coli.

Clone: 8A5C6

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-DKK3 antibody (ABIN1098142)

Du, Kataoka, Sakaguchi, Abarzua, Than, Sonegawa, Makino, Shimizu, Huh: "Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis." in: Experimental dermatology, Vol. 20, Issue 3, pp. 273-7, (2011) (PubMed).

Medinger, Tzankov, Kern, Pircher, Hermann, Ott, Gastl, Untergasser, Gunsilius: "Increased Dkk3 protein expression in platelets and megakaryocytes of patients with myeloproliferative neoplasms." in: Thrombosis and haemostasis, Vol. 105, Issue 1, pp. 72-80, (2011) (PubMed).

Target Details for DKK3

Target: DKK3

Abstract: DKK3 Products

Synonyms: REIC antibody, RIG antibody, reic antibody, dkk-3 antibody, AW061014 antibody, C87148 antibody, Reic antibody, p29 antibody, dickkopf WNT signaling pathway inhibitor 3 antibody, dickkopf WNT signaling pathway inhibitor 3 S homeolog antibody, DKK3 antibody, dkk3 antibody, dkk3.S antibody, Dkk3 antibody

Background:

Description: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.

Aliases: RIG, REIC

Molecular Weight: 38.3kDa

Gene ID: 27122

HGNC: 27122

UniProt: Q9UBP4