TWIST1 antibody (AA 9-74)

Catalog No. ABIN1098133

Product Details anti-TWIST1 Antibody

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Binding Specificity: AA 9-74

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TWIST1 antibody is un-conjugated

Application: ELISA

Purpose: TWIST1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TWIST1 (AA: 9-74) expressed in E. Coli.

Clone: 2F8E7

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TWIST1 antibody (ABIN1098133)

Yu, Li, Lu, Tian, Ma, Wang, Xu: "Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression." in: Journal of cancer research and clinical oncology, Vol. 137, Issue 10, pp. 1487-93, (2011) (PubMed).

Casas, Kim, Bendesky, Ohno-Machado, Wolfe, Yang: "Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis." in: Cancer research, Vol. 71, Issue 1, pp. 245-54, (2011) (PubMed).

Target Details for TWIST1

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Alternative Name: TWIST1 (TWIST1 Products)

Background:

Description: Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue, in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.

Aliases: SCS, ACS3, CRS1, BPES2, BPES3, TWIST, bHLHa38

Molecular Weight: 21kDa

Gene ID: 7291

HGNC: 7291

UniProt: Q15672

Pathways: p53 Signaling, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity