LMO2 antibody (AA 1-158)

Catalog No. ABIN1098128

Product Details anti-LMO2 Antibody

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Binding Specificity: AA 1-158

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LMO2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: LMO2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human LMO2 (AA: 1-158) expressed in E. Coli.

Clone: 4D8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-LMO2 antibody (ABIN1098128)

Cubedo, Maurin, Jiang, Lossos, Wright: "PRDM1/Blimp1 downregulates expression of germinal center genes LMO2 and HGAL." in: The FEBS journal, Vol. 278, Issue 17, pp. 3065-75, (2011) (PubMed).

Baecklund, Backlin, Mansouri, Klareskog, Askling, Iliadou, Enblad, Lossos, Natkunam, Rosenquist: "LMO2 protein expression predicts survival in patients with rheumatoid arthritis and diffuse large B-cell lymphoma." in: Leukemia & lymphoma, Vol. 52, Issue 6, pp. 1146-9, (2011) (PubMed).

Target Details for LMO2

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Alternative Name: LMO2 (LMO2 Products)

Synonyms: Rbtn-2 antibody, Rbtn2 antibody, Rhom-2 antibody, Ttg2 antibody, RBTN2 antibody, RBTNL1 antibody, RHOM2 antibody, TTG2 antibody, wu:fc83a08 antibody, zgc:111930 antibody, LMO-2 antibody, lmo2-A antibody, xlmo2 antibody, rhombotin-2 antibody, LIM domain only 2 antibody, LIM domain only 2 (rhombotin-like 1) antibody, LIM domain only 2 S homeolog antibody, lmo2 antibody, LMO2 antibody, Lmo2 antibody, lmo2.S antibody

Background:

Description: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: TTG2, RBTN2, RHOM2, RBTNL1

Molecular Weight: 18.4kDa

Gene ID: 4005

HGNC: 4005

UniProt: P25791

Pathways: Chromatin Binding