ILK antibody (AA 97-244)

Catalog No. ABIN1098122

Product Details anti-ILK Antibody

Target: ILK (Integrin-Linked Kinase (ILK))

Binding Specificity: AA 97-244

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ILK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: ILK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ILK (AA: 97-244) expressed in E. Coli.

Clone: 3A9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ILK antibody (ABIN1098122)

Taylor, Qiao, Colon, Schlegel, Josifi, Chung: "Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells." in: Surgery, Vol. 150, Issue 2, pp. 162-8, (2011) (PubMed).

Matsui, Assi, Ogawa, Raven, Dedhar, Gleave, Salh, So: "The importance of integrin-linked kinase in the regulation of bladder cancer invasion." in: International journal of cancer. Journal international du cancer, Vol. 130, Issue 3, pp. 521-31, (2011) (PubMed).

Target Details for ILK

Target: ILK (Integrin-Linked Kinase (ILK))

Alternative Name: ILK (ILK Products)

Synonyms: CG10504 antibody, CT29478 antibody, DmILK antibody, Dmel\\CG10504 antibody, ILK antibody, ilk antibody, l(3)78Ca antibody, p59 antibody, AA511515 antibody, ESTM24 antibody, zgc:65842 antibody, ILK-1 antibody, ILK-2 antibody, P59 antibody, p59ILK antibody, Integrin linked kinase antibody, integrin linked kinase antibody, integrin linked kinase S homeolog antibody, integrin-linked protein kinase antibody, integrin-linked kinase antibody, Ilk antibody, ILK antibody, ilk.S antibody, CpipJ_CPIJ016644 antibody, Bm1_20815 antibody, Tsp_07213 antibody, Tsp_07224 antibody, Tsp_15354 antibody, ilk antibody

Background:

Description: Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Aliases: P59, ILK-2

Molecular Weight: 51.4kDa

Gene ID: 3611

HGNC: 3611

UniProt: Q13418

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration