ANXA1
Reactivity: Human
WB, IHC, FACS
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Recommended Dilution: ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000 Not yet tested in other applications. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C or at -20 °C for long term.
Nair, Hande, Lim: "Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage." in: Cancer letters, Vol. 294, Issue 1, pp. 111-7, (2010) (PubMed).
Li, Shen, Huang, Huang, Wang, Wu: "Annexin-I overexpression is associated with tumour progression and independently predicts inferior disease-specific and metastasis-free survival in urinary bladder urothelial carcinoma." in: Pathology, Vol. 42, Issue 1, pp. 43-9, (2009) (PubMed).
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.