PIK3R1 antibody (AA 159-388)

Catalog No. ABIN1098111

Product Details anti-PIK3R1 Antibody

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Binding Specificity: AA 159-388

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PIK3R1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: PIK3R1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PIK3R1 (AA: 159-388) expressed in E. Coli.

Clone: 6G10

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PIK3R1 antibody (ABIN1098111)

Natunen, Martiskainen, Marttinen, Gabbouj, Koivisto, Kemppainen, Kaipainen, Takalo, Svobodová, Leppänen, Kemiläinen, Ryhänen, Kuulasmaa, Rahunen, Juutinen, Mäkinen, Miettinen, Rauramaa, Pihlajamäki et al.: "Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. ..." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 66, (2020) (PubMed).

Kwon, Salinas, Kolb, Fu, Feng, Stanford, Ostrander: "Genetic polymorphisms in inflammation pathway genes and prostate cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 20, Issue 5, pp. 923-33, (2011) (PubMed).

Taniguchi, Winnay, Kondo, Bronson, Guimaraes, Alemán, Luo, Stephanopoulos, Weissleder, Cantley, Kahn: "The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling." in: Cancer research, Vol. 70, Issue 13, pp. 5305-15, (2010) (PubMed).

Target Details for PIK3R1

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Alternative Name: PIK3R1 (PI3K p85a Products)

Synonyms: PI3CG antibody, PI3K antibody, PI3Kgamma antibody, PIK3 antibody, AGM7 antibody, GRB1 antibody, p85 antibody, p85-ALPHA antibody, PI3KA antibody, AA414921 antibody, C530050K14 antibody, p50alpha antibody, p55alpha antibody, p85alpha antibody, wu:fb65b05 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antibody, phosphoinositide-3-kinase regulatory subunit 1 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antibody, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antibody, PIK3CG antibody, PIK3R1 antibody, Pik3r1 antibody, Pik3cb antibody, pik3r1 antibody

Background:

Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.

Aliases: p85, GRB1, p85-ALPHA

Molecular Weight: 83.6kDa

Gene ID: 5295

HGNC: 5295

UniProt: P27986

Pathways: TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect