IGF2 antibody (AA 25-180)

Catalog No. ABIN1098108

Product Details anti-IGF2 Antibody

Target: IGF2 (Insulin-Like Growth Factor 2 (IGF2))

Binding Specificity: AA 25-180

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGF2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: IGF2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human IGF2 (AA: 25-180) expressed in E. Coli.

Clone: 8H1

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IGF2 antibody (ABIN1098108)

El Tayebi, Salah, El Sayed, Salam, Zekri, Zayed, Salem, Esmat, Abdelaziz: "Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients." in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 16, Issue 4, pp. 346-54, (2011) (PubMed).

Shetty, Movva, Pasupuleti, Vedicherlla, Vattam, Venkatasubramanian, Ahuja, Hasan: "Regulation of IGF2 transcript and protein expression by altered methylation in breast cancer." in: Journal of cancer research and clinical oncology, Vol. 137, Issue 2, pp. 339-45, (2011) (PubMed).

Target Details for IGF2

Target: IGF2 (Insulin-Like Growth Factor 2 (IGF2))

Alternative Name: IGF2 (IGF2 Products)

Background:

Description: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Aliases: IGF-II, PP9974, C11orf43, FLJ22066, FLJ44734

Molecular Weight: 20.1kDa

Gene ID: 3481

HGNC: 3481

UniProt: P01344

Pathways: Hormone Activity, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Carbohydrate Metabolic Process, Activated T Cell Proliferation