SRY antibody (AA 1-204)

Catalog No. ABIN1098106

Product Details anti-SRY Antibody

Target: SRY (Sex Determining Region Y (SRY))

Binding Specificity: AA 1-204

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SRY antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: purified

Immunogen: Purified recombinant fragment of human SRY (AA:1-204) expressed in E. coli.

Clone: 1G4

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-SRY antibody (ABIN1098106)

Peng, Ivanov, Oh, Lau, Rauscher: "Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery." in: The Journal of biological chemistry, Vol. 284, Issue 51, pp. 35670-80, (2009) (PubMed).

Wu, Chen, Li, Lau, Shih: "Regulation of monoamine oxidase A by the SRY gene on the Y chromosome." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 11, pp. 4029-38, (2009) (PubMed).

Target Details for SRY

Target: SRY (Sex Determining Region Y (SRY))

Alternative Name: SRY (SRY Products)

Synonyms: SRXX1 antibody, SRXY1 antibody, TDF antibody, TDY antibody, SRYGENE antibody, Sry1 antibody, Sry3BI antibody, Tdf antibody, Tdy antibody, SRY antibody, sex determining region Y antibody, sex determining region of Chr Y antibody, SRY antibody, Sry antibody

Background:

Description: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome), translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.

Aliases: TDF, TDY, SRXX1, SRXY1

Molecular Weight: 23.9 kDa

Gene ID: 6736

HGNC: 6736